Recombinant SARS-CoV-2 spike S1-Fc fusion protein

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced excessive ranges of neutralizing responses in nonhuman primates

 

The COVID-19 outbreak has turn out to be a worldwide pandemic accountable for over 2,000,000 confirmed instances and over 126,000 deaths worldwide. On this research, we examined the immunogenicity of CHO-expressed recombinant SARS-CoV-2 S1-Fc fusion protein in mice, rabbits, and monkeys as a possible candidate for a COVID-19 vaccine. We show that the S1-Fc fusion protein is extraordinarily immunogenic, as evidenced by robust antibody titers noticed by day 7.

 

Sturdy virus neutralizing exercise was noticed on day 14 in rabbits immunized with the S1-Fc fusion protein utilizing a pseudovirus neutralization assay. Most significantly, in <20 days and three injections of the S1-Fc fusion protein, two monkeys developed increased virus neutralizing titers than a recovered COVID-19 affected person in a dwell SARS-CoV-2 an infection assay.

 

Our information strongly means that the CHO-expressed SARS-CoV-2 S1-Fc recombinant protein could possibly be a powerful candidate for vaccine improvement towards COVID-19.
Genoimmun
Genoimmun

 

Key phrases: COVID-19; SARS-CoV-2; Spike protein; Vaccine.

Recombinant Human CDC37 Protein, His, E.coli-2ug

QP11364-HIS-2ug 2ug
EUR 186

Recombinant Human CDC37 Protein, His, E.coli-10ug

QP11364-HIS-10ug 10ug
EUR 241.2

CDC37 Recombinant Protein (Rat)

RP194117 100 ug Ask for price

Recombinant Human CDC37 Protein, Untagged, E.coli-1mg

QP11364-1mg 1mg
EUR 3308.4

Recombinant Human CDC37 Protein, Untagged, E.coli-5ug

QP11364-5ug 5ug
EUR 186

CDC37 Recombinant Protein (Mouse)

RP122837 100 ug Ask for price

Recombinant Human CDC37 Protein, Untagged, E.coli-25ug

QP11364-25ug 25ug
EUR 241.2

Recombinant Mouse CDC37/CDC37A Protein

PKSM040466-100ug 100ug
EUR 940
Description: Mouse

CDC37 Cell Division Cycle 37 Human Recombinant Protein

PROTQ16543 Regular: 25ug
EUR 380.4
Description: CDC37 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids and having a molecular mass of 44.4 kDa.

Recombinant Mouse CDC37/CDC37A Protein (His & GST Tag)

PKSM040467-100ug 100ug
EUR 732
Description: Mouse

Recombinant Candida Albicans CDC37 Protein (aa 1-508)

VAng-Lsx05391-inquire inquire Ask for price
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Hsp90 co-chaperone Cdc37, recombinant protein.

CDC123 Recombinant Protein (Human)

RP051217 100 ug Ask for price

CDC16 Recombinant Protein (Human)

RP006463 100 ug Ask for price

CDC16 Recombinant Protein (Human)

RP006466 100 ug Ask for price

CDC20 Recombinant Protein (Human)

RP006472 100 ug Ask for price

CDC20 Recombinant Protein (Human)

RP006475 100 ug Ask for price

CDC20 Recombinant Protein (Human)

RP006478 100 ug Ask for price

CDC23 Recombinant Protein (Human)

RP006484 100 ug Ask for price

CDC26 Recombinant Protein (Human)

RP006493 100 ug Ask for price

CDC27 Recombinant Protein (Human)

RP006496 100 ug Ask for price

CDC34 Recombinant Protein (Human)

RP006502 100 ug Ask for price

CDC42 Recombinant Protein (Human)

RP006508 100 ug Ask for price

CDC73 Recombinant Protein (Human)

RP006535 100 ug Ask for price

CDC73 Recombinant Protein (Human)

RP006538 100 ug Ask for price

CDC40 Recombinant Protein (Human)

RP037930 100 ug Ask for price

CDC45 Recombinant Protein (Human)

RP051274 100 ug Ask for price

Cdc37 recombinant monoclonal antibody

A5200 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human Cdc37 for WB,ELISA

CDC20B Recombinant Protein (Human)

RP006481 100 ug Ask for price

CDC25A Recombinant Protein (Human)

RP006487 100 ug Ask for price

CDC25C Recombinant Protein (Human)

RP006490 100 ug Ask for price

CDC45L Recombinant Protein (Human)

RP006529 100 ug Ask for price

Cdc14A Recombinant Protein (Human)

RP051220 100 ug Ask for price

CDC14B Recombinant Protein (Human)

RP051223 100 ug Ask for price

CDC14C Recombinant Protein (Human)

RP051226 100 ug Ask for price

CDC25B Recombinant Protein (Human)

RP051232 100 ug Ask for price

CDC37L1 Recombinant Protein (Human)

RP006505 100 ug Ask for price

CDC27P1 Recombinant Protein (Human)

RP051238 100 ug Ask for price

CDC27P2 Recombinant Protein (Human)

RP051241 100 ug Ask for price

CDC42P1 Recombinant Protein (Human)

RP051268 100 ug Ask for price

CDC42P2 Recombinant Protein (Human)

RP051271 100 ug Ask for price

CDC42EP1 Recombinant Protein (Human)

RP006511 100 ug Ask for price

CDC42EP2 Recombinant Protein (Human)

RP006514 100 ug Ask for price

Use of three-dimensionally printed β-tricalcium phosphate artificial bone graft mixed with recombinant human bone morphogenic protein-2 to deal with a extreme radial atrophic nonunion in a Yorkshire terrier

 

Goal: To explain a novel surgical method to deal with a critical-sized bone defect on account of extreme, radial atrophic nonunion in a miniature canine.

 

Research design: Case report ANIMAL: A 1-year-old Yorkshire terrier with a critical-sized left radial defect after failed inner fixation of a transverse radial fracture.

 

Strategies: Computed tomographic (CT) pictures of the radius had been imported for three-dimensional (3D) printing of a custom-designed artificial 3D-printed β-tricalcium phosphate (β-TCP) scaffold. The radius was uncovered, and the β-TCP scaffold was press-fitted within the bone hole beneath the plate.

 

Recombinant human bone morphogenic protein-2 (RhBMP-2) collagen sponges had been squeezed to soak the scaffold with progress issue after which positioned on either side of the artificial graft. Two extra cortical screws had been additionally positioned previous to routine closure of the surgical web site.

 

Outcomes: Radiographic examination was according to full therapeutic of the radius defect four months after surgical procedure. The bone plate was eliminated 10 months after surgical procedure. In line with CT examination 18 months after surgical procedure, there was no proof of the artificial graft; as a substitute, full corticalization of the affected space was famous. Full purposeful restoration was noticed till the final scientific follow-up 36 months postoperatively.

 

Conclusion: Screw fixation and use of a 3D-printed ceramic scaffold augmented with rhBMP-2 resulted in glorious bone regeneration of the nonunion and full restoration of a miniature breed canine.

 

Medical significance: The therapeutic method used on this canine could possibly be thought-about as an choice for therapy of large-bone defects in veterinary orthopedics, particularly for defects affecting the distal radius of miniature canine.

 

Vaccine impact of recombinant single-chain hemagglutinin protein as an antigen

Vaccination is likely one of the handiest interventions for stopping the unfold of influenza viruses on the inhabitants degree. At the moment most influenza vaccines are produced through the use of embryonated rooster eggs, however different strategies that obtain extra speedy large-scale manufacturing are extremely fascinating for vaccines towards each pandemic and seasonal influenza viruses.

 

The usage of recombinant hemagglutinin (HA), a key virus floor protein, as an antigen is a sexy candidate different method, due to the potential for top protein yields and the convenience of cloning new antigenic variants.

 

Though fusion of HA with trimerization domains is required to stabilize the trimeric construction and improve the immunogenicity of the recombinant HA protein, whether or not the trimerization domains are immunogenic should be thought-about.

 

Right here, we generated recombinant multimeric HA with out trimerization domains through the use of a brief peptide linker, termed a single-chain HA (scHA), and evaluated scHAs as potential antigens for producing vaccines towards influenza virus. Utilizing mammalian cells, we succeeded in making three sorts of recombinant scHAs-two dimeric scHAs and a trimeric scHA.

 

After immunization with aluminium salts in mice, one of many dimeric scHAs induced the best HA-specific IgG response among the many scHAs and guarded towards virus problem as strongly because the usually used trimeric HA containing a trimerization area.

 

We didn’t observe IgGs particular for the quick peptide linker in mice immunized with the dimeric scHA, though IgGs particular for the trimerization area occurred in mice immunized with the trimeric HA containing that area. Moreover, altering to a different adjuvant didn’t diminish the utility of the dimeric scHA.

 

These outcomes recommend the potential usefulness of dimeric scHA as a vaccine antigen. We consider that single-chain antigens might symbolize new alternate options for manufacturing of recombinant antigen-based vaccines.

 

Key phrases: Adjuvant; Hemagglutinin; Immunology; Infectious illness; Influenza virus; Microbiology; Pharmaceutical science; Pharmacology; Proteins; Recombinant protein; Vaccine; Virology.

Recombinant Human SOD2/Mn-SOD Protein (His Tag)

PKSH033072-50ug 50ug
EUR 593
Description: Human

Genorise® recombinant human mn-SOD protein

GR119158 5 µg
EUR 285

Recombinant Human SOD2/Mn-SOD Protein (His Tag, Human Cells)

PKSH033071-10ug 10ug
EUR 263
Description: Human

Recombinant Human SOD2/Mn-SOD Protein (His Tag, Human Cells)

PKSH033071-50ug 50ug
EUR 447
Description: Human

Recombinant Human SOD2/Mn-SOD (N-6His)

AP75309 1mg
EUR 1459

Recombinant Human SOD2/Mn-SOD (N-6His)

C677-10ug 10ug
EUR 242.4
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,50% glycerol,pH 8.0.

Recombinant Human SOD2/Mn-SOD (N-6His)

C677-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,50% glycerol,pH 8.0.

Recombinant Human SOD2/Mn-SOD (N-6His)

C677-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,50% glycerol,pH 8.0.

Recombinant Human SOD2/Mn-SOD (N-6His)

C677-50ug 50ug
EUR 595.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,50% glycerol,pH 8.0.

Genorise® recombinant Mouse mn-SOD protein

GR124158 5 µg
EUR 285

Recombinant Human SOD2/Mn-SOD (C-6His, Human Cells)

CB01-10ug 10ug
EUR 175.2
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.

Recombinant Human SOD2/Mn-SOD (C-6His, Human Cells)

CB01-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.

Recombinant Human SOD2/Mn-SOD (C-6His, Human Cells)

CB01-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.

Recombinant Human SOD2/Mn-SOD (C-6His, Human Cells)

CB01-50ug 50ug
EUR 363.6
Description: Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.

SOD Superoxide Dismutase Human Recombinant Protein

PROTP00441 Regular: 100ug
EUR 380.4
Description: Recombinant Human Cu/Zn Superoxide Dismutase produced in E.Coli is a non-glycosylated homodimeric polypeptide chain containing 2 x 153 amino acids and having a total molecular mass of 31.6kDa. 

Recombinant MARV sod (aa 1-202) Protein

VAng-Wyb3558-1mgEcoli 1 mg (E. coli)
EUR 4184.4
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) superoxide dismutase protein, recombinant protein.

Recombinant MARV sod (aa 1-202) Protein

VAng-Wyb3558-500gEcoli 500 µg (E. coli)
EUR 2997.6
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) superoxide dismutase protein, recombinant protein.

Recombinant MARV sod (aa 1-202) Protein

VAng-Wyb3558-50gEcoli 50 µg (E. coli)
EUR 2040
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) superoxide dismutase protein, recombinant protein.

Recombinant Human Cu/Zn SOD

HEENP-0301 100ug Ask for price

Mn SOD Protein

SPR-130A 0.05 mg
EUR 468
Description: Rat Recombinant Mn SOD Protein

Mn SOD Protein

SPR-130B 0.1 mg
EUR 867
Description: Rat Recombinant Mn SOD Protein

Mn SOD Protein

SPR-130C 2x0.1 mg
EUR 1561
Description: Rat Recombinant Mn SOD Protein

Mn SOD Protein

SPR-131A 0.05 mg
EUR 468
Description: Human Recombinant Mn SOD Protein

Mn SOD Protein

SPR-131B 0.1 mg
EUR 867
Description: Human Recombinant Mn SOD Protein

Mn SOD Protein

SPR-131C 2x0.1 mg
EUR 1561
Description: Human Recombinant Mn SOD Protein

Mn SOD Protein

abx675016-100g 100 µg
EUR 700

Mn SOD Protein

abx675017-100g 100 µg
EUR 700

Recombinant Human Cu/Zn SOD, His

HEENP-0302 100ug Ask for price

Superoxide Dismutase (SOD), human recombinant

4802-100 each
EUR 464.4

Superoxide Dismutase (SOD), human recombinant

4802-1000 each
EUR 2734.8

Superoxide Dismutase (SOD), human recombinant

4802-20 each
EUR 242.4

Superoxide Dismutase 2 (SOD-2), human recombinant

6360-100 each
EUR 457.2

Recombinant (Sf9) HIV-1 gp120 MN envelop protein

RP-546-10 10 ug
EUR 416.4

Recombinant Human Mn Superoxide Dismutase

13003P 1000ug
EUR 3229

Recombinant Human Mn Superoxide Dismutase

13003P-1000 1000ug
EUR 3229

Recombinant Human Mn Superoxide Dismutase

13003P-25 25ug
EUR 287

Recombinant Human Mn Superoxide Dismutase

13003P-5 5ug
EUR 169

SOD2 Recombinant Protein (Human)

RP029686 100 ug Ask for price

SOD2 Recombinant Protein (Human)

RP029689 100 ug Ask for price

SOD3 Recombinant Protein (Human)

RP029692 100 ug Ask for price

Recombinant Human SOD1 Protein, His Tag

E40KMH1735 20ug
EUR 495

Recombinant Human SOD2 Protein, His Tag

E40KMH1737 20ug
EUR 495

Recombinant HIV-1 gp120 MN Protein, Untagged, Insect-2ug

QP12246-2ug 2ug
EUR 186

Recombinant HIV-1 gp120 MN Protein, Untagged, Insect-10ug

QP12246-10ug 10ug
EUR 316.8

Recombinant Schistosoma Mansoni EC-SOD Protein (aa 19-184)

VAng-Cr3577-1mgEcoli 1 mg (E. coli)
EUR 3921.6
Description: Schistosoma Mansoni (Blood fluke) extracellular superoxide dismutase [Cu-Zn] (EC-SOD), recombinant protein.

Recombinant Schistosoma Mansoni EC-SOD Protein (aa 19-184)

VAng-Cr3577-500gEcoli 500 µg (E. coli)
EUR 2799.6
Description: Schistosoma Mansoni (Blood fluke) extracellular superoxide dismutase [Cu-Zn] (EC-SOD), recombinant protein.

Recombinant Schistosoma Mansoni EC-SOD Protein (aa 19-184)

VAng-Cr3577-50gEcoli 50 µg (E. coli)
EUR 1924.8
Description: Schistosoma Mansoni (Blood fluke) extracellular superoxide dismutase [Cu-Zn] (EC-SOD), recombinant protein.

Recombinant HIV-1 gp120 MN Protein, Untagged, Insect-100ug

QP12246-100ug 100ug
EUR 2230.8

Recombinant Human SOD2 Protein, His, E.coli-1mg

QP10866-1mg 1mg
EUR 2774.4

Recombinant Human SOD2 Protein, His, E.coli-5ug

QP10866-5ug 5ug
EUR 186

Recombinant Human SOD2 Protein, His, E.coli-25ug

QP10866-25ug 25ug
EUR 241.2

Human SOD2 Recombinant Protein C-6His Tag

IHUSOD2RC6HIS10UG each
EUR 299
Description: Human SOD2 Recombinant Protein C-6His Tag

Recombinant human Sodium channel protein

P2866 100ug Ask for price
Description: Recombinant protein for human Sodium channel protein